Innate immune response, especially type 1 interferon (IFN) response is considered to play a substantial role in the outcome of SARS-CoV-2 infection. A reduced and delayed IFN response has been associated with progression to severe COVID-19. In this study, we investigated levels of circulating IFNα and serum neutralizing activity in COVID-19 patients admitted to the intensive care unit. We found a significant association of levels of IFNα with age ( p = 0.007). This association has also been observed in a cohort of COVID-19 outpatients with mild infection ( p = 0.02). The impact of senescence on IFN response can explain the higher susceptibility of the elderly to severe COVID-19.
All Keywords
【저자키워드】 SARS-CoV-2, severe COVID-19, Neutralizing antibodies, age, IFNα, 【초록키워드】 immune response, intensive care, SARS-COV-2 infection, susceptibility, progression, outcome, serum, Neutralizing activity, Cohort, IFN, mild infection, association, IFNα, Innate, IFN response, COVID-19 patient, circulating, type 1 interferon, investigated, reduced, explain, COVID-19 outpatient, 【제목키워드】 COVID-19, Level,
【저자키워드】 SARS-CoV-2, severe COVID-19, Neutralizing antibodies, age, IFNα, 【초록키워드】 immune response, intensive care, SARS-COV-2 infection, susceptibility, progression, outcome, serum, Neutralizing activity, Cohort, IFN, mild infection, association, IFNα, Innate, IFN response, COVID-19 patient, circulating, type 1 interferon, investigated, reduced, explain, COVID-19 outpatient, 【제목키워드】 COVID-19, Level,