The exact mechanisms leading to myocardial injury in the coronavirus disease 2019 (COVID-19) are still unknown. In this retrospective observational study, we include all consecutive COVID-19 patients admitted to our center. They were divided into two groups according to the presence of myocardial injury. Clinical variables, Charlson Comorbidity Index (CCI), C-reactive protein (CRP), CAC (COVID-19-associated coagulopathy), defined according to the ISTH score, treatment and in-hospital events were collected. Between March and April 2020, 331 COVID-19 patients were enrolled, 72 of them (21.8%) with myocardial injury. Patients with myocardial injury showed a higher CCI score (median (interquartile range), 5 (4–7) vs. 2 (1–4), p = 0.001), higher CRP values (18.3 (9.6–25.9) mg/dL vs. 12.0 (5.4–19.4) mg/dL, p ˂ 0.001) and CAC score (1 (0–2) vs. 0 (0–1), p = 0.001), and had lower use of any anticoagulant (57 patients (82.6%) vs. 229 patients (90.9%), p = 0.078), than those without. In the adjusted logistic regression, CRP, myocardial injury, CCI and CAC score were positive independent predictors of mortality, whereas anticoagulants resulted as a protective factor. Myocardial injury in COVID-19 patients is associated with inflammation and coagulopathy, resulting in a worse in-hospital prognosis. Treatment with anticoagulant agents may help to improve in-hospital outcomes.
【저자키워드】 Coronavirus disease 2019, Mortality, Coagulopathy, myocardial injury, 【초록키워드】 COVID-19, Treatment, coronavirus disease, Inflammation, Prognosis, C-reactive protein, CRP, outcomes, clinical, Patient, Logistic regression, mechanism, Anticoagulant, retrospective, Injury, COVID-19 patient, In-hospital, interquartile range, Charlson Comorbidity Index, help, protective factor, positive, event, IMPROVE, enrolled, defined, resulting, collected, include, median, adjusted, two group, anticoagulant agent, CCI, CRP value, independent predictor, variables, 【제목키워드】 COVID-19,