The Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has rapidly spread to become a global pandemic, putting a strain on health care systems. SARS-CoV-2 infection may be associated with mild symptoms or, in severe cases, lead patients to the intensive care unit (ICU) or death. The critically ill patients suffer from acute respiratory distress syndrome (ARDS), sepsis, thrombotic complications and multiple organ failure. For optimization of hospital resources, several molecular markers and algorithms have been evaluated in order to stratify COVID-19 patients, based on the risk of developing a mild, moderate, or severe disease. Here, we propose the soluble urokinase receptor (suPAR) as a serum biomarker of clinical severity and outcome in patients who are hospitalized with COVID-19. In patients with mild disease course, suPAR levels were increased as compared to healthy controls, but they were dramatically higher in severely ill patients. Since early identification of disease progression may facilitate the individual management of COVID-19 symptomatic patients and the time of admission to the ICU, we suggest paying more clinical attention on patients with high suPAR levels.
【저자키워드】 COVID-19, ARDS, Biomarkers, complement system, suPAR, Sepsis, risk stratification in the emergency room, 【초록키워드】 SARS-CoV-2, Coronavirus disease 2019, Biomarker, Hospitalized, intensive care, SARS-COV-2 infection, risk, outcome, ICU, global pandemic, Disease progression, serum, management, Algorithm, Patient, death, severe cases, Mild, receptor, molecular, multiple organ failure, Admission, moderate, COVID-19 patients, acute respiratory distress, marker, Clinical severity, severe disease, health care systems, Critically ill patient, Mild symptom, syndrome, healthy controls, severely ill patients, hospital resources, thrombotic complication, Course, caused, spread to, evaluated, facilitate, COVID-19 symptomatic patient, with COVID-19, with mild disease, 【제목키워드】 prediction, urokinase,