Together, chronic obstructive pulmonary disease (COPD) and asthma account for the most common non-infectious respiratory pathologies. Conflicting preliminary studies have shown varied effect for COPD and asthma as prognostic factors for mortality in coronavirus disease 2019 (COVID-19). The aim of this study was to explore the association of COPD and asthma with in-hospital mortality in patients with COVID-19 by systematically reviewing and synthesizing with a meta-analysis the available observational studies. MEDLINE, Scopus, and medRxiv databases were reviewed. A random-effects model meta-analysis was used, and I-square was utilized to assess for heterogeneity. In-hospital mortality was defined as the primary endpoint. Sensitivity and meta-regression analyses were performed. Thirty studies with 21,309 patients were included in this meta-analysis (1465 with COPD and 633 with asthma). Hospitalized COVID-19 patients with COPD had higher risk of death compared to those without COPD (OR: 2.29; 95% CI: 1.79–2.93; I 2 59.6%). No significant difference in in-hospital mortality was seen in patients with and without asthma (OR: 0.87; 95% CI: 0.68–1.10; I 2 0.0%). The likelihood of death was significantly higher in patients with COPD that were hospitalized with COVID-19 compared to patients without COPD. Further studies are needed to assess whether this association is independent or not. No significant difference was demonstrated in COVID-19-related mortality between patients with and without asthma.
【저자키워드】 COVID-19, Meta-analysis, Asthma, Mortality, chronic obstructive pulmonary disease (COPD), 【초록키워드】 coronavirus disease, Hospitalized, database, heterogeneity, observational studies, COPD, Patient, death, in-hospital mortality, pulmonary disease, association, COVID-19 patient, Prognostic factor, significant difference, higher risk, random-effects model, non-infectious, likelihood, independent, respiratory pathologies, defined, shown, performed, was used, demonstrated, significantly higher, chronic obstructive, meta-regression analysis, patients with COVID-19, the primary endpoint, with COVID-19, 【제목키워드】 review, COPD, assessment, with COVID-19,