Coronavirus Disease 19 (COVID-19), due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become an on-going global health emergency affecting over 94 million cases with more than 2 million deaths globally. Primarily identified as atypical pneumonia, it has developed into severe acute respiratory distress syndrome (ARDS), a multi-organ dysfunction with associated fatality. Ever since its emergence, COVID-19 with its plethora of clinical presentations has signalled its dynamic nature and versatility of the disease process. Being a disease with droplet transmission has now assumed the proportion of a suspected airborne nature which, once proved, poses a Herculean task to control. Because of the wide distribution of the human angiotensin-converting enzyme-2 (hACE2) receptors, known for its transmission, we envisage its multiorgan spread and extensive disease distribution. Thus, an extensive review of the extrapulmonary organotropism of SARS-CoV-2 with organ-specific pathophysiology and associated manifestations like dermatological complications, myocardial dysfunction, gastrointestinal symptoms, neurologic illnesses, hepatic and renal injury is needed urgently. The plausible mechanism of site-specific viral invasion is also discussed to give a comprehensive understanding of disease complexity, to help us to focus on research priorities and therapeutic strategies to counter the disease progression. A note on the latest advancements in vaccine research will enlighten the scientific world and equip it for better preparedness.
【저자키워드】 COVID-19, SARS-CoV-2, Pathogenesis, Vaccines, Therapeutics, ACE-2, neurological, hepatic, dermatological, 【초록키워드】 ARDS, Vaccine, multi-organ dysfunction, Pneumonia, Transmission, progression, hACE2, Spread, pathophysiology, droplet transmission, Research, death, complications, receptors, angiotensin-converting enzyme-2, distribution, disease, mechanism, therapeutic strategy, Multiorgan, acute respiratory distress, fatality, Coronavirus-2, gastrointestinal symptoms, Injury, clinical presentation, Atypical, manifestation, Myocardial dysfunction, health emergency, acute respiratory syndrome, syndrome, help, plethora, viral invasion, renal, illnesses, being, neurologic, proportion, the disease, affecting, assumed, organ-specific, organotropism of SARS-CoV-2, 【제목키워드】 pulmonary, manifestation, Involvement,