COVID-19 is currently considered an inflammatory disease affecting the entire organism. In severe forms, an augmented inflammatory response leads to the fulminant “cytokine storm”, which may result in severe multisystemic end-organ damage. Apart from the acute inflammatory response, it seems that chronic inflammation also plays a major role in the clinical evolution of COVID-19 patients. Pre-existing inflammatory conditions, such as those associated with chronic coronary diseases, type 2 diabetes mellitus or obesity, may be associated with worse clinical outcomes in the context of COVID-19 disease. These comorbidities are reported as powerful predictors of poor outcomes and death following COVID-19 disease. Moreover, in the context of chronic coronary syndrome, the cytokine storm triggered by SARS-CoV-2 infection may favor vulnerabilization and rupture of a silent atheromatous plaque, with consequent acute coronary syndrome, leading to a sudden deterioration of the clinical condition of the patient. This review aims to present the current status of knowledge regarding the link between COVID-19 mortality, systemic inflammation and several major diseases associated with poor outcomes, such as cardiovascular diseases, diabetes and obesity.
【저자키워드】 Inflammation, Cytokine storm, obesity, type 2 diabetes, Chronic coronary syndrome, 【초록키워드】 COVID-19, Diseases, knowledge, SARS-COV-2 infection, Comorbidity, cardiovascular diseases, outcome, COVID-19 disease, Clinical outcome, outcomes, Deterioration, death, chronic inflammation, systemic inflammation, predictor, disease, COVID-19 patients, Inflammatory response, COVID-19 mortality, favor, organism, clinical condition, clinical evolution, inflammatory conditions, inflammatory disease, rupture, forms, end-organ damage, acute inflammatory response, reported, the patient, triggered, affecting, diabete, silent, “cytokine storm”, coronary syndrome, severe multisystemic, the cytokine storm, type 2 diabete, 【제목키워드】 COVID-19, systemic, chronic, Major, Coronary,