Background Individuals with intellectual and developmental disabilities (IDD) living in congregated settings have increased risk of COVID-19 infection and mortality. Little is known about variant B.1.1.519 with spike mutation T478K, dominant in Mexico. We describe a linked SARS-CoV-2 B.1.1.519 outbreak in three IDD facilities in the Netherlands. Methods Following notification of the index, subsequent cases were identified through serial PCR group testing. Positive specimens were submitted for whole-genome-sequencing. Clinical information was gathered through interviews with staff members of the three facilities. Results Attack rate (AR) in clients of the index facility was 92% (23/25), total AR in clients 45% (33/73) and in staff members 24% (8/34). 55% (18/33) of client cases were asymptomatic, versus 25% (2/8) of staff members. Five client cases (15%) were hospitalized, two died (6%). Sequencing yielded the same specific B.1.1.519 genotype in all three facilities. No significant difference in median viral load was established comparing the B.1.1.519 variant with other circulating variants. The index of the linked outbreak reported no travel history or link to suspected or confirmed cases suggesting regional surveillance. Observed peak regional prevalence of B.1.1.519 during the outbreak supports this. Conclusion AR, morbidity and mortality prior to control measures taking effect were high, probably related to the specific characteristics of the IDD setting and its clients. We assessed no evidence for intrinsic contributing properties of variant B.1.1.519. Our study argues for enhanced infection prevention protocols in the IDD setting, and prioritization of this group for vaccination against COVID-19. Supplementary Information The online version contains supplementary material available at 10.1186/s12879-022-07121-y.
【저자키워드】 SARS-CoV-2, outbreak, Infection prevention and control, Intellectual and developmental disability, B.1.1.519 variant, T478K spike mutation, 【초록키워드】 protocol, Hospitalized, Mortality, Sequencing, variant, Prevalence, Viral, PCR, Characteristics, Asymptomatic, Surveillance, COVID-19 infection, spike mutation, attack rate, clinical, morbidity, Travel, Genotype, Infection prevention, morbidity and mortality, information, developmental disabilities, Evidence, Netherlands, Support, confirmed case, T478K, notification, index, significant difference, supplementary material, no significant difference, increased risk, individual, clinical information, specimen, Median viral load, measure, circulating variants, attack, dominant, vaccination against COVID-19, intrinsic, Result, died, reported, subsequent, submitted, developmental, Observed, 【제목키워드】 SARS-CoV-2 variant, T478K, nosocomial COVID-19, Netherland, developmental,