Our aim was to assess the seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection after the lockdown in a sample of the Corsican population. Between 16 April and 15 June 2020, 2312 residual sera were collected from patients with a blood analysis conducted in one of the participating laboratories. Residual sera obtained from persons of all ages were tested for the presence of anti-SARS-CoV-2 Immunoglobulin G (IgG) using the EUROIMMUN enzyme immunoassay kit for semiquantitative detection of IgG antibodies against the S1 domain of viral spike protein (ELISA-S). Borderline and positive samples in ELISA-S were also tested with an in-house virus neutralization test (VNT). Prevalence values were adjusted for sex and age. A total of 1973 residual sera samples were included in the study. The overall seroprevalence based on ELISA-S was 5.27% (95% confidence interval (CI), 4.33–6.35) and 5.46% (4.51–6.57) after adjustment. Sex was not associated with IgG detection. However, significant differences were observed between age groups ( p -value = 1 E-5). The highest values were observed among 10–19, 30–39, and 40–49 year-old age groups, ranging around 8–10%. The prevalence of neutralizing antibody titers ≥40 was 3% (2.28–3.84). In conclusion, the present study showed a low seroprevalence for COVID-19 in Corsica, a finding that is in accordance with values reported for other French regions in which the impact of the pandemic was low.
【저자키워드】 antibodies, SARS-CoV-2, Seroprevalence, ELISA, France, seroneutralization, 【초록키워드】 COVID-19, IgG, pandemic, lockdown, Infection, Sex, anti-SARS-CoV-2, Prevalence, immunoassay, Immunoglobulin G, Region, IgG antibody, sera, virus neutralization test, Patient, age, group, Euroimmun, Blood, Neutralizing antibody titer, Coronavirus-2, Analysis, viral spike protein, acute respiratory syndrome, significant difference, 95% confidence interval, enzyme, P -value, French, positive sample, borderline, S1 domain, Corsica, VNT, residual, highest, tested, collected, reported, conducted, adjusted, groups, 【제목키워드】 SARS-CoV-2 IgG, Corsica,