Background: The immunomodulatory effects of vitamin D are known to be beneficial in viral infections; it is also known that its deficiency is associated with a prognosis more critical of Coronavirus Disease 2019. This study aimed to determine baseline vitamin D serum concentrations and the effects of its supplementation in asymptomatic or mildly symptomatic Coronavirus Disease 2019 outpatients. Methods: 42 outpatients were included, 22 of which received a supplement of 10,000 IU of vitamin D3 for 14 days; the remaining 20 outpatients were designated as a control group. Serum levels of transferrin, ferritin, vitamin D, and D-dimer were measured at baseline in both groups. After 14 days, serum levels of total vitamin D were determined in the supplemented group. Results: At baseline, only 19% of infected outpatients had vitamin D levels corresponding to sufficiency. All outpatients with vitamin D insufficiency had at least one symptom associated with the disease, while only 75% of patients with symptoms presented sufficiency. On the seventh and fourteenth day of follow-up, the supplemented group presented fewer symptoms with respect to those non-supplemented. A vitamin D3 dose of 10,000 IU/daily for 14 days was sufficient to raise vitamin D serum concentrations. Conclusions: Immunomodulatory effects of vitamin D appear to be linked to the development of symptoms in positive outpatients. Vitamin D supplementation could have significant benefits in the Western Mexican population.
【저자키워드】 COVID-19, SARS-CoV-2, coronavirus, Vitamin D, cholecalciferol, Latin America, Supplementation, Biochemical parameters, ergocalciferol, 【초록키워드】 Prognosis, vitamin D insufficiency, D-dimer, ferritin, Symptom, Asymptomatic, symptomatic, Transferrin, Patient, outpatients, Follow-up, Critical, Outpatient, Concentration, dose, deficiency, control group, Serum level, vitamin D level, positive, immunomodulatory effect, Effect, benefit, concentrations, raise, the disease, determine, in viral, were measured, baseline, in both groups, supplemented group, vitamin D serum, 【제목키워드】 clinical, Outpatient, Effect, Level,