The coronavirus pandemic continues to challenge global healthcare. Severely affected patients are often in need of high doses of analgesics and sedatives. The latter was studied in critically ill coronavirus disease 2019 (COVID-19) patients in this prospective monocentric analysis. COVID-19 acute respiratory distress syndrome (ARDS) patients admitted between 1 April and 1 December 2020 were enrolled in the study. A statistical analysis of impeded sedation using mixed-effect linear regression models was performed. Overall, 114 patients were enrolled, requiring unusual high levels of sedatives. During 67.9% of the observation period, a combination of sedatives was required in addition to continuous analgesia. During ARDS therapy, 85.1% ( n = 97) underwent prone positioning. Veno-venous extracorporeal membrane oxygenation (vv-ECMO) was required in 20.2% ( n = 23) of all patients. vv-ECMO patients showed significantly higher sedation needs ( p < 0.001). Patients with hepatic ( p = 0.01) or renal ( p = 0.01) dysfunction showed significantly lower sedation requirements. Except for patient age ( p = 0.01), we could not find any significant influence of pre-existing conditions. Age, vv-ECMO therapy and additional organ failure could be demonstrated as factors influencing sedation needs. Young patients and those receiving vv-ECMO usually require increased sedation for intensive care therapy. However, further studies are needed to elucidate the causes and mechanisms of impeded sedation.
【저자키워드】 severe acute respiratory syndrome coronavirus 2, Prone position, Critical care, acute respiratory distress syndrome, pulmonary ventilation, hypnotics and sedatives, 【초록키워드】 COVID-19, coronavirus disease, ARDS, High dose, coronavirus, pandemic, therapy, intensive care, extracorporeal membrane oxygenation, Critically ill, Patient, age, patients, mechanism, acute respiratory distress, Combination, Analysis, statistical analysis, Organ failure, prone positioning, dysfunction, Sedation, Factor, syndrome, observation period, renal, global healthcare, significantly lower, Linear regression model, enrolled, affected, addition, required, receiving, was performed, demonstrated, significantly higher, cause, conditions, 【제목키워드】 COVID-19, ARDS, Factor, sedative, Requirement,