This study aimed to achieve a better understanding of the epidemiological and clinical characteristics of multisystem inflammatory syndrome in children (MIS-C) following coronavirus disease 2019 (COVID-19). We searched PubMed and Embase between December 2019 and March 2021 and included only peer-reviewed clinical studies or case series. The proportions of patients who had conjunctivitis, systemic symptoms/signs (s/s), Kawasaki disease (KD), and exposure history to suspected/confirmed COVID-19 cases were obtained. Moreover, positive rates of the nasopharyngeal real-time reverse transcriptase polymerase chain reaction (RT-PCR) and serum antibody for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were recorded. Overall, 32 studies with 1458 patients were included in the pooled analysis. Around half of the patients had conjunctivitis. The five most common systemic manifestations were fever (96.4%), gastrointestinal s/s (76.7%), shock (61.5%), rash (57.1%), and neurological s/s (36.8%). Almost one-third presented complete KD and about half had exposure history to COVID-19 cases. The positivity of the serology (82.2%) was higher than that of the nasopharyngeal RT-PCR (37.0%). MIS-C associated with COVID-19 leads to several features similar to KD. Epidemiological and laboratory findings suggest that post-infective immune dysregulation may play a predominant role. Further studies are crucial to elucidate the underlying pathogenesis.
【저자키워드】 COVID-19, Meta-analysis, SARS-CoV-2, Multisystem inflammatory syndrome, conjunctivitis, 【초록키워드】 coronavirus disease, coronavirus, Pathogenesis, Clinical characteristics, serology, children, RT-PCR, MIS-C, Laboratory, Shock, Case series, nasopharyngeal, Kawasaki disease, Fever, Patient, epidemiological, serum antibody, positive rate, Rash, clinical study, Analysis, Inflammatory, COVID-19 cases, neurological, immune dysregulation, acute respiratory syndrome, COVID-19 case, syndrome, Complete, FIVE, feature, polymerase chain, real-time reverse transcriptase, proportion, the patient, searched, predominant, peer-reviewed, were recorded, systemic manifestation, with COVID-19, 【제목키워드】 manifestation, systemic, with COVID-19,