Background The impact of COVID-19 has been devastating on a global scale. The negative conversion time (NCT) of SARS-CoV-2 RNA is closely related to clinical manifestation and disease progression in COVID-19 patients. Our study aimed to predict factors associated with prolonged NCT of SARS-CoV-2 RNA in mild/moderate COVID-19 patients. Methods The clinical features, laboratory data and treatment outcomes of COVID-19 patients were retrospectively analyzed. Then univariate and multivariate analysis were used to screen out risk factors of influencing prolonged NCT of SARS-CoV-2 RNA. Results Thirty-two hospitalized mild/moderate COVID-19 patients were enrolled. The general clinical symptoms were cough (78.1%), fever (75%), diarrhea (68.8%), expectoration (56.3%), and nausea (37.5%). More than 40% of the patients had decreased erythrocyte, hemoglobin and leucocyte and 93.8% patients were detected in abnormalities of chest CT. The median NCT of SARS-CoV-2 RNA was 19.5 days (IQR: 14.25–25). Univariate analysis found fever, nausea, diarrhea and abnormalities in chest CTs were positively associated with prolonged NCT of viral RNA ( P < 0.05). The multivariate Cox proportional hazard model revealed that fever [Exp (B), 0.284; 95% CI, 0.114–0.707; P <0.05] and nausea [Exp (B), 0.257; 95%CI, 0.096–0.689; P <0.05] were two significant independent factors. Conclusions Fever and nausea were two significant independent factors in prolonged NCT of viral RNA in mild/moderate COVID-19 patients, which provided a useful references for disease progression and treatment of COVID-19. Supplementary Information The online version contains supplementary material available at 10.1186/s12879-021-05851-z.
【저자키워드】 COVID-19, SARS-CoV-2, Clinical characteristics, Negative conversion time, 【초록키워드】 Treatment, Treatment outcome, Risk factors, Hospitalized, risk factor, cough, diarrhea, Clinical features, Disease progression, Viral, Chest CT, Fever, Patient, Factors, SARS-CoV-2 RNA, Viral RNA, hemoglobin, predict, COVID-19 patients, Multivariate analysis, Analysis, COVID-19 patient, leucocyte, clinical manifestation, Factor, treatment of COVID-19, supplementary material, 95%CI, 95% CI, Negative conversion, clinical symptom, laboratory data, expectoration, nausea, Abnormalities, Univariate analysis, abnormality, erythrocyte, independent, Result, enrolled, analyzed, the patient, provided, median, were used, 【제목키워드】 Hospitalized, Characteristics, clinical, COVID-19 patient, Negative conversion, SARS-CoV-2 nucleic acid,