Coronavirus disease 2019 (COVID-19) infection causes acute lung injury, resulting from aggressive inflammation initiated by viral replication. There has been much speculation about the potential role of non-steroidal inflammatory drugs (NSAIDs), which increase the expression of angiotensin-converting enzyme 2 (ACE2), a binding target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to enter the host cell, which could lead to poorer outcomes in COVID-19 disease. The aim of this study was to examine the association between routine use of NSAIDs and outcomes in hospitalised patients with COVID-19. This was a multicentre, observational study, with data collected from adult patients with COVID-19 admitted to eight UK hospitals. Of 1222 patients eligible to be included, 54 (4.4%) were routinely prescribed NSAIDs prior to admission. Univariate results suggested a modest protective effect from the use of NSAIDs, but in the multivariable analysis, there was no association between prior NSAID use and time to mortality (adjusted HR (aHR) = 0.89, 95% CI 0.52–1.53, p = 0.67) or length of stay (aHR 0.89, 95% CI 0.59–1.35, p = 0.58). This study found no evidence that routine NSAID use was associated with higher COVID-19 mortality in hospitalised patients; therefore, patients should be advised to continue taking these medications until further evidence emerges. Our findings suggest that NSAID use might confer a modest benefit with regard to survival. However, as this finding was underpowered, further research is required.
【저자키워드】 COVID-19, SARS-CoV-2, NSAIDS, Non-steroidal anti-inflammatory drugs, 【초록키워드】 Inflammation, Coronavirus disease 2019, ACE2, coronavirus, Mortality, Infection, drug, outcome, angiotensin-converting enzyme 2, acute lung injury, COVID-19 disease, survival, viral replication, Research, Patient, multicentre, medication, expression, Admission, protective effect, binding, association, Evidence, NSAID, Inflammatory, COVID-19 mortality, host cell, acute respiratory syndrome, 95% CI, multivariable analysis, UK hospitals, hospitalised, benefit, resulting, collected, required, eight, adjusted, suggested, hospitalised patient, initiated, cause, eligible, patients with COVID-19, with COVID-19, 【제목키워드】 drug, routine, with COVID-19,