It is unclear to which extent the higher mortality associated with hypertension in the coronavirus disease (COVID-19) is due to its increased prevalence among older patients or to specific mechanisms. Cross-sectional, observational, retrospective multicenter study, analyzing 12226 patients who required hospital admission in 150 Spanish centers included in the nationwide SEMI-COVID-19 Network. We compared the clinical characteristics of survivors versus non-survivors. The mean age of the study population was 67.5 ± 16.1 years, 42.6% were women. Overall, 2630 (21.5%) subjects died. The most common comorbidity was hypertension (50.9%) followed by diabetes (19.1%), and atrial fibrillation (11.2%). Multivariate analysis showed that after adjusting for gender (males, OR: 1.5, p = 0.0001), age tertiles (second and third tertiles, OR: 2.0 and 4.7, p = 0.0001), and Charlson Comorbidity Index scores (second and third tertiles, OR: 4.7 and 8.1, p = 0.0001), hypertension was significantly predictive of all-cause mortality when this comorbidity was treated with angiotensin-converting enzyme inhibitors (ACEIs) (OR: 1.6, p = 0.002) or other than renin-angiotensin-aldosterone blockers (OR: 1.3, p = 0.001) or angiotensin II receptor blockers (ARBs) (OR: 1.2, p = 0.035). The preexisting condition of hypertension had an independent prognostic value for all-cause mortality in patients with COVID-19 who required hospitalization. ARBs showed a lower risk of lethality in hypertensive patients than other antihypertensive drugs.
【저자키워드】 COVID-19, hypertension, angiotensin II receptor blockers (ARBS), all-cause mortality, angiotensin-converting enzyme inhibitors (ACEIs), 【초록키워드】 coronavirus disease, Mortality, Hospitalization, Clinical characteristics, Comorbidity, Gender, ARB, Prevalence, Atrial fibrillation, older patient, Patient, age, network, Hospital admission, mechanisms, receptor, women, Multivariate analysis, angiotensin-converting enzyme inhibitor, ACEIs, ARBs, Predictive, antihypertensive drugs, Non-survivors, Prognostic value, study population, subject, Charlson Comorbidity Index, lower risk, blocker, Retrospective multicenter study, survivor, Spanish, males, independent, died, significantly, required, treated, diabete, hypertensive patient, patients with COVID-19, 【제목키워드】 with COVID-19,