Background Our goal is to further elucidate the clinical condition and prognosis of patients with severe acute COVID-19 with EBV reactivation. Method This is a retrospective single-center study of COVID-19 patients admitted to the intensive care unit of Wuhan No. 3 Hospital (January 31 to March 27, 2020). According to whether Epstein-Barr virus reactivation was detected, the patients were divided into an EBV group and a Non-EBV group. Baseline data were collected including epidemiological, larithmics, clinical and imaging characteristics, and laboratory examination data. Results Of the 128 patients with COVID-19, 17 (13.3%) were infected with Epstein-Barr virus reactivation. In the symptoms,the rate of tachypnoea in the EBV group was apparently higher than that in the Non-EBV group. In lab tests, the lymphocyte and albumin of EBV group decreased more significantly than Non-EBV group, and the D-dimer and serum calcium of EBV group was higher than Non-EBV group. Regarding the infection index, CRP of EBV group was apparently above the Non-EBV group, and no significant difference was found in procalcitonin of the two groups. The incidence of respiratory failure, ARDS, and hypoproteinaemia of EBV group had more incidence than Non-EBV group. The 28-day and 14-day mortality rates of EBV group was significantly higher than that of Non-EBV group. Conclusions In the COVID-19 patients, patients with EBV reactivation had higher 28-day and 14-day mortality rates and received more immuno-supportive treatment than patients of Non-EBV group.
【저자키워드】 SARS-CoV-2, outcome, Epstein-Barr virus, 【초록키워드】 Treatment, ARDS, Respiratory failure, intensive care, Prognosis, Infection, intensive care unit, CRP, D-dimer, procalcitonin, laboratory examination, virus, Laboratory, lymphocyte, Characteristics, Wuhan, Patient, albumin, Epstein-Barr virus, epidemiological, mortality rate, incidence, calcium, EBV, COVID-19 patients, retrospective, COVID-19 patient, Supportive treatment, No. 3, two groups, no significant difference, single-center study, baseline data, acute COVID-19, clinical condition, serum calcium, tachypnoea, lab, Result, were infected, collected, significantly, the patient, significantly higher, prognosis of patient, had more, patients with COVID-19, 【제목키워드】 virus, Characteristics, clinical, Critically ill patient, acute COVID-19,