COVID-19, as a disease involving the endothelium of multiple organs, is characterized by high mortality rates among hospitalized patients. Patients with hematological malignancies are particularly at risk of an unfavorable course of COVID-19. The endothelial activation and stress index (EASIX) score has been used as a simple predictor of overall survival (OS) in specific groups of hematological cancer patients. EASIX, as a biomarker of endothelial dysfunction, might play a prognostic role in patients with COVID-19. Here, we performed a comprehensive retrospective analysis of the EASIX score in 523 hospitalized COVID-19 patients with or without coexisting hematological cancer. Hematological cancer COVID-19 patients had higher EASIX scores compared to the overall population with COVID-19. In hematological patients, EASIX was a strong predictor of the occurrence of sepsis during COVID-19. Our findings demonstrated EASIX as a strong predictor of intensive care unit admission, in-hospital mortality, the occurrence of acute renal failure and the need for hemodialysis, both in hematological and non-hematological COVID-19 patients. Patients with a high EASIX score on COVID-19 diagnosis had significantly inferior OS compared to patients with low EASIX. We showed for the first time that EASIX might serve as a simple, universal prognostic tool of OS in both hematological and non-hematological COVID-19 patients.
【저자키워드】 COVID-19, lactate dehydrogenase, Endothelial dysfunction, EASIX, Platelet count, creatinine, hematological cancer, 【초록키워드】 Biomarker, intensive care, Stress, Hematological malignancy, Cancer, risk, Sepsis, hospitalized patients, Endothelium, survival, Hemodialysis, Patient, COVID-19 diagnosis, Cancer patients, Retrospective analysis, prognostic, group, disease, Admission, patients, in-hospital mortality, COVID-19 patients, hospitalized COVID-19 patient, acute renal failure, COVID-19 patient, endothelial, Activation, multiple organs, hematological, high mortality rate, Occurrence, Course, performed, significantly, characterized, demonstrated, patients with COVID-19, with COVID-19, 【제목키워드】 index,