Background. Some patients previously presenting with COVID-19 have been reported to develop persistent COVID-19 symptoms. While this information has been adequately recognised and extensively published with respect to non-critically ill patients, less is known about the incidence and factors associated with the characteristics of persistent COVID-19. On the other hand, these patients very often have intensive care unit-acquired pneumonia (ICUAP). A second infectious hit after COVID increases the length of ICU stay and mechanical ventilation and could have an influence on poor health post-COVID 19 syndrome in ICU-discharged patients. Methods: This prospective, multicentre, and observational study was carrid out across 40 selected ICUs in Spain. Consecutive patients with COVID-19 requiring ICU admission were recruited and evaluated three months after hospital discharge. Results: A total of 1255 ICU patients were scheduled to be followed up at 3 months; however, the final cohort comprised 991 (78.9%) patients. A total of 315 patients developed ICUAP (97% of them had ventilated ICUAP). Patients requiring invasive mechanical ventilation had more persistent post-COVID-19 symptoms than those who did not require mechanical ventilation. Female sex, duration of ICU stay, development of ICUAP, and ARDS were independent factors for persistent poor health post-COVID-19. Conclusions: Persistent post-COVID-19 symptoms occurred in more than two-thirds of patients. Female sex, duration of ICU stay, development of ICUAP, and ARDS all comprised independent factors for persistent poor health post-COVID-19. Prevention of ICUAP could have beneficial effects in poor health post-COVID-19
【저자키워드】 COVID-19, SARS-CoV-2, ICU, Post-COVID, sequelae, Lung function, CT abnormalities, 【초록키워드】 ARDS, intensive care, mechanical ventilation, Pneumonia, Sex, prevention, Symptom, COVID, Health, Characteristics, Patient, ICU admission, Spain, multicentre, incidence, persistent, information, patients, Invasive mechanical ventilation, Persistent COVID-19 symptoms, Factor, Ventilated, hospital discharge, syndrome, while, non-critically ill patients, Effect, ICU patient, independent, selected, develop, occurred, recruited, reported, evaluated, increase, less, presenting, final cohort, had more, patients with COVID-19, with COVID-19, 【제목키워드】 Poor,