Background: In coronavirus disease 2019 (COVID-19) patients, increases in high-sensitive cardiac troponin T (hs-cTnT) have been reported to be associated with worse outcomes. In the critically ill, the prognostic value of hs-cTnT, however, remains to be assessed given that most previous studies have involved a case mix of non- and severely ill COVID-19 patients. Methods: We conducted, from March to May 2020, in three French intensive care units (ICUs), a multicenter retrospective cohort study to assess in-hospital mortality predictability of hs-cTnT levels in COVID-19 patients. Results: 111 laboratory-confirmed COVID-19 patients (68% of male, median age 67 (58–75) years old) were included. At ICU admission, the median Charlson Index, Simplified Acute Physiology Score II, and PaO 2 /FiO 2 were at 3 (2–5), 37 (27–48), and 140 (98–154), respectively, and the median hs-cTnT serum levels were at 16.0 (10.1–31.9) ng/L. Seventy-five patients (68%) were mechanically ventilated, 41 (37%) were treated with norepinephrine, and 17 (15%) underwent renal replacement therapy. In-hospital mortality was 29% (32/111) and was independently associated with lower PaO 2 /FiO 2 and higher hs-cTnT serum levels. Conclusions: At ICU admission, besides PaO 2 /FiO 2 , hs-cTnT levels may allow early risk stratification and triage in critically ill COVID-19 patients.
【저자키워드】 COVID-19, SARS-CoV-2, ICU, outcomes, myocardial injury, high-sensitive cardiac troponin T, 【초록키워드】 coronavirus disease, Mortality, intensive care unit, cardiac troponin, risk stratification, Critically ill, Physiology, male, Patient, ICU admission, multicenter, patients, score, in-hospital mortality, COVID-19 patients, renal replacement therapy, COVID-19 patient, case mix, retrospective cohort study, index, Prognostic value, Serum level, median age, serum levels, ICUs, mechanically ventilated, previous study, French, laboratory-confirmed, involved, reported, conducted, treated, increases in, PaO, the median, 【제목키워드】 multicenter study, troponin T, cardiac, increase, Level, Ill,