Background In patients receiving single lung transplantation for idiopathic pulmonary fibrosis, worsening of fibrosis of the native lung is usually progressive over time, with no significant effects on gas exchange. Case presentation Here, we describe the cases of two Caucasian male recipients of single lung transplants for idiopathic pulmonary fibrosis, 65 and 62 years of age, who exhibited acute worsening of lung fibrosis after an episode of serious viral infection (cytomegalovirus primo-infection in one case and COVID-19 in the other). In both cases, along with opacification of the native lung over several days, the patients presented acute respiratory failure that required the use of high-flow nasal oxygen therapy. Eventually, hypoxemic respiratory failure resolved, but with rapid progression of fibrosis of the native lung. Conclusion We conclude that acute worsening of fibrosis on the native lung secondary to a severe viral infection should be added to the list of potential complications developing on the native lung after single lung transplantation for idiopathic pulmonary fibrosis.
【저자키워드】 Lung infection, Idiopathic pulmonary fibrosis, Hypoxemia, Lung fibrosis, lung transplantation, 【초록키워드】 COVID-19, viral infection, therapy, Respiratory failure, pulmonary fibrosis, High-flow nasal oxygen, lung, fibrosis, progression, Gas exchange, male, Patient, Complication, age, lung transplant, no significant effect, worsening, recipient, hypoxemic, the patient, required, receiving, exhibited, added, resolved, 【제목키워드】 lung, Case report, worsening,