Abstract Introduction: Coronavirus disease 2019 (COVID-19) is a rapidly emerging infectious respiratory disease caused by severe acute respiratory syndrome coronavirus 2. Currently, more than 100 million cases of COVID-19 have been confirmed worldwide, with over 2.4 million mortalities. The pandemic affects people of all ages but older individuals and those with severe chronic illnesses, including cancer patients, are at higher risk. Patient concerns: The impact of cancer treatment on the progression of COVID-19 is unclear. Therefore, we assessed the effects of chemotherapy on COVID-19 outcomes for 2 cancer patients. On January 24, 2020, a level I response to a major public health emergency was initiated in Hubei Province, China, which includes Enshi Autonomous Prefecture that has a population of 4.026 million people. As of April 30, 2020, 252 confirmed cases of COVID-19 and 11 asymptomatic carriers were identified in Enshi. Diagnosis: Among the confirmed cases and asymptomatic carriers, 2 patients were identified who were previously diagnosed with malignant tumors, including one with hepatocellular carcinoma and the other with cardia carcinoma. Interventions: These 2 patients were receiving or just completed chemotherapy at the time of their COVID-19 diagnosis. Outcomes: Both patients were followed and presented favorable outcomes. The positive outcomes for these 2 patients could be partially explained by their recent chemotherapy that impacted their immune status. Also, their relatively younger ages and lack of comorbidities were likely factors in their successful recovery from COVID-19. Conclusions: Anticancer treatment might enhance a patient’s ability to respond favorably to COVID-19 infection. However, anticancer treatment is likely to impact immune function differently in different individuals, which can influence disease outcomes.
【저자키워드】 Coronavirus disease 2019, Chemotherapy, immune function, carcinoma, gastrointestinal tumors, 【초록키워드】 COVID-19, Treatment, coronavirus, pandemic, Comorbidity, Asymptomatic carrier, progression, outcome, China, outcomes, COVID-19 infection, Respiratory disease, Patient, COVID-19 diagnosis, Cancer patients, Asymptomatic carriers, age, public health emergency, disease, cancer treatment, Immune status, Hepatocellular carcinoma, confirmed case, acute respiratory syndrome, Older, Factor, higher risk, individual, chronic illnesses, anticancer, positive, mortalities, Effect, Affect, ENhance, malignant tumors, lack, caused, include, diagnosed, receiving, explained, initiated, individuals, respond, impacted, 【제목키워드】 Tumor, Immunity, Case report, COVID-19 case,