Abstract Background: Coronavirus disease 2019 (COVID-19) is one of the infectious diseases that have seriously threatened global public health since its outbreak in 2019. Due to the complicated Pathogenesis, high infectivity and high fatality rate of COVID-19, there is currently no effective treatment for such epidemic disease. Traditional Chinese medicine has a long clinical history for the prevention and treatment of this kind of acute infectious disease. Qingfei Paidu Decoction (QFPD) is widely used in treating COVID-19 in China. However, there is still a lack of comprehensive and systematic evidence on the effectiveness and safety of Qingfei Paidu Decoction. Methods: We will search each database from the built-in until May 2020. The English literature mainly searches Cochrane Library, PubMed, EMBASE, and Web of Science, while the Chinese literature comes from CNKI, CBM, VIP, and Wangfang database. Simultaneously we will retrieval clinical registration tests and grey literatures. This study only screen the clinical randomized controlled trials (RCTs) about QFPD for COVID-19 to assess its efficacy and safety. The two researchers worked independently on literature selection, data extraction, and quality assessment. The dichotomous data is represented by relative risk (RR), and the continuous is expressed by mean difference (MD) or standard mean difference (SMD), eventually the data is synthesized using a fixed effect model (FEM) or a random effect model (REM) depending on whether or not heterogeneity exists. Total clinical effective rate, improvement rate of lung CT, adverse events were evaluated as the main outcomes. Effective rate of clinical symptoms, treatment time were secondary outcomes. Finally, meta-analysis was conducted by RevMan software version 5.3. Results: The results of our research will be published in a peer-reviewed journal. Conclusion: This systematic review aims to provide new evidence of QFPD for COVID-19 in terms of its efficacy and safety. PROSPERO registration number: CRD42020200894.
【저자키워드】 COVID-19, Meta-analysis, protocol, systematic review, Qingfei Paidu decoction, 【초록키워드】 Randomized controlled trial, Treatment, Coronavirus disease 2019, Clinical symptoms, Traditional Chinese medicine, risk, Infectious disease, database, heterogeneity, China, outcomes, Epidemic, outbreak, adverse event, Research, Effectiveness, Efficacy and safety, disease, RCTs, Evidence, Lung CT, Decoction, Web of Science, Secondary outcomes, global public health, data extraction, Chinese, Fatality rate, Cochrane Library, acute infectious disease, mean difference, treating COVID-19, CNKI, random effect model, researcher, clinical history, SMD, effective, English, lack, evaluated, conducted, expressed, fixed, Total, peer-reviewed, CBM, REM, VIP, 【제목키워드】 Randomized controlled trial, treating COVID-19,