Abstract Background: The pandemic following the rapid spread of the new SARS-CoV-2 virus has hit all continents and caused thousands of deaths worldwide. Evidence has been published on epidemiological and clinical characteristics of population groups considered at risk; however, information for the other population groups, especially for the child population, is needed. In this context, this protocol describes a systematic review that will aim to identify the evidence on control and prevention of COVID-19 transmission among children and adolescents, as well as to describe the epidemiological profile and clinical and immunological characteristics of COVID-19 in this population. Methods: This protocol will be developed in accordance with PRISMA-P. The searches will be conducted in PubMed, Web of Science, ScienceDirect, EMBASE, and Scopus, seeking clinical trials. Observational studies and case reports with Children and adolescents (≤19 years) infected with SARS-CoV-2 will be included whether they report information on the control of prevention and COVID-19 transmission. Two independent researchers will perform the selection of articles, removal of duplication, and screening by Rayyan QCRI application. Cochrane’s RoB 2.0, ROBINS-I, and CASP tools will be used to assess the risk of bias. Meta-analysis, subgroup analyses, and/or descriptive analyses will be carried out based on the data conditions included. Results: A high-quality synthesis of the available evidences on the epidemiological profile, the clinical and immunological characteristics involved in children, and adolescents diagnosed with COVID-19, as well as the participation of this population in the transmission dynamics of SARS-CoV-2 will be provided. Conclusion: This systematic review has an important relevance in the current context because it has a great potential to help the development of new control and prevention strategies in the pediatric population. Record of systematic review: CRD42020179263.
【저자키워드】 COVID-19, SARS-COV-2 infection, children, adolescents, 【초록키워드】 SARS-CoV-2, pandemic, protocol, Clinical characteristics, pediatric, clinical trials, systematic review, Transmission, virus, observational study, Case report, Spread, Risk of bias, Transmission dynamics, death, epidemiological, group, information, Evidence, Analysis, COVID-19 transmission, Web of Science, help, Record, duplication, researcher, immunological characteristics, articles, independent, new SARS-CoV-2, Casp, prevention of COVID-19, identify, caused, carried, involved, conducted, provided, condition, groups, analyses, diagnosed with COVID-19, infected with SARS-CoV-2, RoB, seeking, 【제목키워드】 review, prevention, Control,