Abstract Rationale: The clinical manifestations of the SARS-CoV-2 infection are mainly respiratory but the virus can cause a variety of symptoms. Dermatological findings are less well-characterized. Data is scarce on their timing, type and correlation with the immune response. Patient concerns: We present the case of SARS-CoV-2 infection in a previously healthy woman who presented with respiratory symptoms and developed anosmia, diarrhea, and an erythematous maculo-papular rash on day 15 from symptom onset. Diagnosis: The nasopharyngeal swab tested by real time PCR for COVID-19 was positive. We interpreted this as a viral exanthema likely caused by an immune response to SARS-CoV-2 nucleotides. Interventions: She was treated with Hydroxychloroquine, Azithromycin and Lopinavir/Ritonavir, and the rash with topical corticosteroids. Outcomes: All symptoms resolved except for anosmia which persisted for 6 weeks. At the 4- and 6-weeks follow-up the IgG titers for SARS-CoV-2 were high. Lessons: We must consider that SARS-CoV-2 has a multi-organ tropism. In our case, the SARS-CoV-2 infection had lung, nasopharyngeal, neurological, digestive, and skin manifestations. Identifying the different manifestations is useful for understanding the extent of SARS-CoV-2 infection. We not only present a rare manifestation but also suggest that cutaneous manifestations may correlate with immunity.
【저자키워드】 SARS-CoV-2, immune response, Anosmia, clinical manifestations, Exanthema, 【초록키워드】 COVID-19, Corticosteroids, Lopinavir/ritonavir, Azithromycin, Immunity, SARS-COV-2 infection, Infection, lung, Symptom, diarrhea, virus, Symptoms, Nasopharyngeal swab, PCR, nasopharyngeal, Manifestations, Follow-up, correlation, Rash, IgG titer, real time, neurological, nucleotides, manifestation, cutaneous manifestation, clinical manifestation, symptom onset, respiratory symptom, positive, identifying, tested, caused, healthy, treated, less, variety, digestive, resolved, erythematous, the SARS-CoV-2, 【제목키워드】 SARS-COV-2 infection, Case report,