Abstract Rationale: Infection with the severe acute respiratory coronavirus disease 2019 (COVID-19) has been shown to cause multi-organ involvement including cardiopulmonary serosal layers infection and inflammation. As a result, pericarditis and pericardial effusion may occur with or without COVID-19 related respiratory signs. Due to limitations in sensitivity and specificity of current COVID-19 diagnostic studies, cases that trigger high clinical intuition, even with negative serologic and polymerase chain reaction testing results, may necessitate further diagnostic workup to discover the underlying etiology. Patient concerns: Here we present a rare case of pericardial effusion in the setting of asymptomatic COVID-19 infection manifesting with the chief complaint of chest pain. Diagnosis: While undergoing diagnostic workup, the patients first 2 sets of COVID 19 reverse transcription-polymerase chain reaction (RT-PCR) were negative while a latter RT-PCR test, as well as serology, were positive, leading to the diagnosis of COVID-19 reinfection or subacute presentation of viral infection with pericardial effusion. Echocardiogram depicted large circumferential pericardial effusion with mildly thickened pericardium. Interventions: The patient underwent pericardial window placement followed by ibuprofen administration and discharged from the hospital. Outcomes: During the follow-up visit patient had no symptoms and echocardiogram demonstrated complete resolution of the effusion. Lessons: Due to the possible establishment of pericardial effusions and consecutively tamponade even without any COVID-19 related clinical presentation, it is crucial for clinicians to trust their intuition, conduct the appropriate diagnostic tests, find the underlying diagnosis and prevent the devastating consequences.
【저자키워드】 COVID-19, Case report, Asymptomatic, pericardial effusion, tamponade, 【초록키워드】 Inflammation, viral infection, serology, hospital, Infection, Cardiopulmonary, diagnostic, Diagnosis, Symptom, RT-PCR, COVID 19, Consequences, Reinfection, Sensitivity and specificity, diagnostic tests, Patient, Follow-up, etiology, disease, administration, RT-PCR test, chest pain, Asymptomatic COVID-19, Echocardiogram, clinician, limitation, positive, while, Complete, Prevent, Respiratory Coronavirus, polymerase chain, diagnostic workup, shown, the patient, occur, demonstrated, had no, discharged, diagnosis of COVID-19, 【제목키워드】 Infection, Asymptomatic COVID-19,