Abstract Background: On March 11, 2020, World Health Organization announced that severe acute respiratory syndrome coronavirus 2 caused COVID-19 was a global pandemic. COVID-19 is associated with venous thromboembolism including deep vein thrombosis and pulmonary embolism. To further identify the current role of antiplatelet/anticoagulant therapy in the prophylaxis and treatment of COVID-19 patients is important. Methods: We will conduct a systematic review based on searches of major databases (eg, Pubmed, Web of Science, EMBASE, CENTRAL, MEDLINE, SCI-EXPANDED, CPCI-S, CBM, CNKI, and Wanfang Database) and clinical trial registries from inception to present without limitations of language and publication status. All published randomized control trials, quasi-randomized trials, retrospective and observational studies related to prophylactic antiplatelet/anticoagulant for severe COVID-19 will be included. Primary outcome includes incident acute thrombosis events. Second outcome is the incidence and severity of adverse effects. Full-text screening, data extraction and quality assessment will be conducted by 2 reviewers independently. The reporting quality, risk of bias, sensitivity analysis and subgroup analysis will be performed to ensure the reliability of our findings by other 2 researchers. The statistical analysis will be performed by RevMan V.5.3 software and Stata V.12.0 software. Results: The result of this systematic review will provide valid advice and consultation for clinicians on the management of prophylactic antiplatelet/anticoagulant for severe COVID-19 patients. Conclusion: This systematic review will provide evidence for prophylactic antiplatelet/anticoagulant of severe COVID-19 patients. PROSPERO registration: CRD42020186928.
【저자키워드】 COVID-19, Prophylaxis, Thromboembolism, antiplatelet/anticoagulant, 【초록키워드】 Treatment, coronavirus, therapy, thrombosis, severe COVID-19, reliability, severity, systematic review, outcome, Prophylactic, database, Venous Thromboembolism, observational study, global pandemic, adverse effects, management, Risk of bias, sensitivity analysis, incidence, trials, Randomized control trials, Evidence, retrospective, statistical analysis, COVID-19 patient, World Health Organization, acute respiratory syndrome, Web of Science, clinician, severe COVID-19 patients, data extraction, limitation, subgroup analysis, CNKI, second, researchers, identify, performed, caused, include, conducted, events, CBM, clinical trial registry, 【제목키워드】 Meta-analysis, protocol, thrombosis, severe COVID-19, systematic review, Patient, event,