Ferret coronaviruses (FRCoVs) exist as an enteric and a systemic pathotype, of which the latter is highly lethal to ferrets. To our knowledge, this study provides the first full genome sequence of a FRCoV, tentatively called FRCoV-NL-2010, which was detected in 2010 in ferrets in The Netherlands. Phylogenetic analysis showed that FRCoV-NL-2010 is most closely related to mink CoV, forming a separate clade of mustelid alphacoronavirus that split off early from other alphacoronaviruses. Based on sequence homology of the complete genome, we propose that these mustelid coronaviruses may be assigned to a new species. Comparison of FRCoV-NL-2010 with the partially sequenced ferret systemic coronavirus MSU-1 and ferret enteric coronavirus MSU-2 revealed that recombination in the spike, 3c and envelope genes occurred between different FRCoVs.
【저자키워드】 Recombination, alphacoronavirus, Complete genome, ferret coronavirus, 【초록키워드】 coronavirus, knowledge, Genome, ferret, clade, CoV, alphacoronaviruses, Analysis, genome sequence, Netherlands, sequence homology, ferrets, envelope gene, Complete, occurred, sequenced, provide, assigned, 【제목키워드】 coronavirus, Genome, Complete, Naturally,