In some subjects with inherited pheochromocytoma/paraganglioma (PPG) syndromes, hypoxia-inducible factor 1 alpha (HIF1α) stabilization/activation could lead to an increase in angiotensin converting enzymes (ACE). This would result in the stimulation of angiotensin (AT) II production and, hence, reduce the availability of ACE 2. The latter would provide decreased numbers of binding sites for the spike protein of SARS-CoV-2 and, therefore, result in less points of viral entry into cells. Thus, subjects with HIF1α-associated PPG syndromes may benefit from an inherent protective effect against COVID-19. Such an implication of HIF1α vis-à-vis COVID-19 could open ways of therapeutic interventions.
All Keywords
【저자키워드】 COVID-19, angiotensin-converting enzyme 2, Angiotensin II, adrenal gland neoplasms, pheochromocytoma, hypoxia-inducible factor 1, alpha subunit, 【초록키워드】 SARS-CoV-2, viral entry, binding site, cells, Alpha, protective effect, ACE, in some, subject, enzyme, syndrome, therapeutic interventions, benefit, less, the spike protein, increase in, reduce, inherent, PPG, 【제목키워드】 Paraganglioma,
【저자키워드】 COVID-19, angiotensin-converting enzyme 2, Angiotensin II, adrenal gland neoplasms, pheochromocytoma, hypoxia-inducible factor 1, alpha subunit, 【초록키워드】 SARS-CoV-2, viral entry, binding site, cells, Alpha, protective effect, ACE, in some, subject, enzyme, syndrome, therapeutic interventions, benefit, less, the spike protein, increase in, reduce, inherent, PPG, 【제목키워드】 Paraganglioma,