The adverse effects of the COVID-19 vaccine have been discovered as the rapid application of the vaccines continues. Neurological complications such as transverse myelitis raise concerns as cases were observed in clinical trials. Transverse myelitis is a rare immune-mediated disease with spinal cord neural injury, resulting in neurological deficits in the motor, sensory, and autonomic system. Vaccine-related transverse myelitis is even rarer. We present a case of acute transverse myelitis after vaccination against COVID-19 with the ChAdOx1 nCOV-19 vaccine (AZD1222), which was the first case reported in Taiwan. Although it rarely occurs, post-vaccination neurological complications should not be ignored. As the pandemic of SARS-CoV-2 continues to spread and concern about vaccination efficacy and safety rises, heterologous vaccination were implemented in health public policy in several countries. A literature review of several clinical trials shows promising effects of mix-and-match vaccination. Further study on different combinations of vaccines can be expected.
【저자키워드】 COVID-19, Vaccine, transverse myelitis, 【초록키워드】 SARS-CoV-2, COVID-19 vaccine, vaccination, clinical trial, pandemic, clinical trials, Spread, AZD1222, Health, Complication, Taiwan, ChAdOx1, Heterologous, Combination, Injury, Neurological complication, literature review, adverse effect, vaccination efficacy, Effect, Neurological deficit, vaccination against COVID-19, immune-mediated disease, raise, resulting, reported, the vaccine, expected, autonomic, rises, 【제목키워드】 Myelitis, Transverse,