ABSTRACT Background SARS-CoV-2 is continuously disseminating worldwide. The development of strategies to break transmission is mandatory. Aim of the study To investigate the potential of cetylpyridinium chloride (CPC) as a viral inhibitor. Methods SARS-CoV-2 Virus Like-Particles (VLPs) were incubated with CPC, a potent surfactant routinely included in mouthwash preparations. Results Concentrations of 0.05% CPC (w/v) commonly used in mouthwash preparations are sufficient to promote the rupture of SARS-CoV-2 VLP membranes. Conclusion Including CPC in mouthwashes could be a prophylactic strategy to keep SARS-CoV-2 from spreading.
All Keywords
【저자키워드】 SARS-CoV-2, Virology, virus-like particles, cetylpyridinium chloride, membrane disaggregation, 【초록키워드】 Transmission, inhibitor, VLP, membranes, rupture, VLPs, Result, promote, incubated, Including, mandatory, mouthwashe, prophylactic strategy, w/v, 【제목키워드】 chloride, Virus-like particle, Cetylpyridinium, promote,
【저자키워드】 SARS-CoV-2, Virology, virus-like particles, cetylpyridinium chloride, membrane disaggregation, 【초록키워드】 Transmission, inhibitor, VLP, membranes, rupture, VLPs, Result, promote, incubated, Including, mandatory, mouthwashe, prophylactic strategy, w/v, 【제목키워드】 chloride, Virus-like particle, Cetylpyridinium, promote,