The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic has proven a challenge to healthcare systems since its first appearance in late 2019. The global spread and devastating effects of coronavirus disease 2019 (COVID-19) on patients have resulted in countless studies on risk factors and disease progression. Overweight and obesity emerged as one of the major risk factors for developing severe COVID-19. Here we review the biology of coronavirus infections in relation to obesity. In particular, we review literature about the impact of adiposity-related systemic inflammation on the COVID-19 disease severity, involving cytokine, chemokine, leptin, and growth hormone signaling, and we discuss the involvement of hyperactivation of the renin-angiotensin-aldosterone system (RAAS). Due to the sheer number of publications on COVID-19, we cannot be completed, and therefore, we apologize for all the publications that we do not cite.
【저자키워드】 COVID-19, SARS-CoV-2, obesity, immunopathology, RAAS, 【초록키워드】 coronavirus disease, Coronavirus infection, pandemic, severe COVID-19, cytokine, risk factor, chemokine, Spread, Disease progression, Patient, systemic inflammation, growth hormone, Signaling, overweight, Healthcare system, COVID-19 disease severity, Hyperactivation, Effect,