The physiopathologic characteristics of COVID-19 (high levels of inflammatory cytokines and T-cell reduction) promote fungal colonization and infection, which can go unnoticed because the symptoms in both diseases are very similar. The objective of this work was to study the current epidemiology of systemic mycosis in COVID-19 times. A literature search on the subject (January 2020–February 2021) was performed in PubMed, Embase, Cochrane Library, and LILACS without language restrictions. Demographic data, etiological agent, risk factors, diagnostic methods, antifungal treatment, and fatality rate were considered. Eighty nine publications were found on co-infection by COVID-19 and pneumocystosis, candidiasis, aspergillosis, mucormycosis, coccidioidomycosis, or histoplasmosis. In general, the co-infections occurred in males over the age of 40 with immunosuppression caused by various conditions. Several species were identified in candidiasis and aspergillosis co-infections. For diagnosis, diverse methods were used, from microbiological to molecular. Most patients received antifungals; however, the fatality rates were 11–100%. The latter may result because the clinical picture is usually attributed exclusively to SARS-CoV-2, preventing a clinical suspicion for mycosis. Diagnostic tests also have limitations beginning with sampling. Therefore, in the remainder of the pandemic, these diagnostic limitations must be overcome to achieve a better patient prognosis.
【저자키워드】 COVID-19, Mucormycosis, Co-infection, aspergillosis, pneumocystosis, candidiasis, systemic mycoses, endemic mycosis, 【초록키워드】 SARS-CoV-2, pandemic, Risk factors, Prognosis, Epidemiology, diagnostic test, Infection, diagnostic, Diagnosis, Immunosuppression, Symptom, Characteristics, clinical picture, male, Patient, age, molecular, T-cell, diagnostic methods, demographic, disease, fungal, Inflammatory cytokine, Antifungal treatment, reduction, Mycosis, subject, clinical suspicion, LILACS, Fatality rate, Cochrane Library, limitation, etiological agent, occurred, caused, Most patient, nine, was performed, were used, overcome, promote, conditions, 【제목키워드】 systemic, Mycose,