Aims To search for biochemical indicators that can identify symptomatic patients with COVID-19 whose nucleic acid could turn negative within 14 days, and assess the prognostic value of these biochemical indicators in patients with COVID-19. Patients and methods We collected the clinical data of patients with COVID-19 admitted to our hospital, by using logistic regression analysis and AUC curves, explored the relationship between biochemical indicators and nucleic acid positive duration, the severity of COVID-19, and hospital stay respectively. Results A total of two hundred and thirty-three patients with COVID-19 were enrolled in the study. We found patients whose nucleic acid turned negative within 14 days had lower LDH, CRP and higher ALB ( P < 0.05). ROC curve results indicated that lower LDH, TP, CRP and higher ALB predicted the nucleic acid of patients turned negative within 14 days with statistical significance( P < 0.05), AST, LDH, CRP and PCT predicted the severe COVID-19 with statistical significance, and CRP predicted hospital stay >31days with statistical significance ( P < 0.05). After verification, the probability of nucleic acid turning negative within 14 days in patients with low LDH (<256 U/L), CRP (<44.5 mg/L) and high ALB (>35.8 g/L) was about 4 times higher than that in patients with high LDH, CRP and low ALB ( P < 0.05). Conclusions LDH, CRP and ALB are useful prognostic marker for predicting nucleic acid turn negative within 14 days in symptomatic patients with COVID-19.
【저자키워드】 COVID-19, quarantine, C-reactive protein, procalcitonin, lactate dehydrogenase, AST, 【초록키워드】 severe COVID-19, hospital, LDH, CRP, Probability, nucleic acid, Symptomatic patients, severity of COVID-19, Patient, Prognostic marker, ROC Curve, AUC, Hospital stay, Prognostic value, Logistic regression analysis, biochemical, Clinical data, statistical significance, verification, positive, PCT, statistical, Result, enrolled, predicted, identify, collected, indicated, turn, ALB, patients with COVID-19, symptomatic patient, with COVID-19, 【제목키워드】 LDH, CRP, predict, turn, ALB, symptomatic patient, with COVID-19,