The disease (COVID-19) novel coronavirus pandemic has so far infected millions resulting in the death of over a million people as of Oct 2020. More than 90% of those infected with COVID-19 show mild or no symptoms but the rest of the infected cases show severe symptoms resulting in significant mortality. Age has emerged as a major factor to predict the severity of the disease and mortality rates are significantly higher in elderly patients. Besides, patients with underlying conditions like Type 2 diabetes, cardiovascular diseases, hypertension, and cancer have an increased risk of severe disease and death due to COVID-19 infection. Obesity has emerged as a novel risk factor for hospitalization and death due to COVID-19. Several independent studies have observed that people with obesity are at a greater risk of severe disease and death due to COVID-19. Here we review the published data related to obesity and overweight to assess the possible risk and outcome in Covid-19 patients based on their body weight. Besides, we explore how the obese host provides a unique microenvironment for disease pathogenesis, resulting in increased severity of the disease and poor outcome.
【저자키워드】 COVID-19, Inflammation, coronavirus, obesity, insulin resistance, innate and adaptive immunity, 【초록키워드】 pandemic, Mortality, Hospitalization, severity, Cancer, risk, cardiovascular diseases, diabetes, outcome, risk factor, elderly patients, hypertension, Novel coronavirus, COVID-19 infection, Patient, death, Mild, mortality rate, disease, predict, severe disease, disease pathogenesis, no symptom, increased risk, obese, microenvironment, Host, independent, greater, resulting, the disease, provide, unique, underlying condition, significantly higher, Type, severe symptom, infected case, infected with COVID-19, 【제목키워드】 obese, Host,