Since the first case of COVID-19 was reported in Wuhan, China, in December 2019, the SARS-CoV-2 epidemic has spread all over the world and has become a significant public health issue. The development of treatments for COVID-19 is currently in progress; however, their effects remain limited, and the development of more effective therapeutics is desired. Thus, sufficient understanding of the pathophysiology of COVID-19 is essential to develop effective therapeutics for this disease. Pathological analyses in particular play an important role to demonstrate the causal link between an infectious disease and the pathogen and elucidate the mechanism of pathogenesis. As per pathological analyses to date, respiratory organs are identified as the major affected organs in most COVID-19 cases; also, various lesions were noted in other organs. Further, there have been increasing reports that show that the immune responses of the host contribute to the deterioration of the pathological condition of COVID-19, and a novel concept of MIS-C/MIS-A is also being established. Thus, in this article, we have provided an overview of the pathology of COVID-19 from a histopathological and immunological perspective focusing on the mechanisms of COVID-19 pathogenesis.
【저자키워드】 COVID-19, SARS-CoV-2, pathology, Pathogenesis, Immunity, 【초록키워드】 public health, immune response, Infectious disease, Spread, Deterioration, Epidemic, COVID-19 pathogenesis, pathogen, pathophysiology, disease, mechanism, lesion, Perspective, other organs, organ, causal link, pathological condition, Host, Effect, immunological, effective, Wuhan, China, pathological, affected, develop, reported, provided, contribute, analysis, histopathological, the SARS-CoV-2, treatments for COVID-19, 【제목키워드】 insight,