Here we report on the humoral and cellular immune response in eight volunteers who autonomously chose to adhere to the Italian national COVID-19 vaccination campaign more than 3 months after receiving a single-administration GRAd-COV2 vaccine candidate in the context of the phase-1 clinical trial. We observed a clear boost of both binding/neutralizing antibodies as well as T-cell responses upon receipt of the heterologous BNT162b2 or ChAdOx1-nCOV19 vaccines. These results, despite the limitation of the small sample size, support the concept that a single dose of an adenoviral vaccine may represent an ideal tool to effectively prime a balanced immune response, which can be boosted to high levels by a single dose of a different vaccine platform.
【저자키워드】 public health, Vaccines, 【초록키워드】 Vaccine, immune response, clinical trial, antibody, Cellular immune response, T-cell Response, BNT162b2, COVID-19 vaccination, vaccine candidate, vaccine platform, Heterologous, boost, single dose, humoral, Support, small sample size, National, Volunteer, Italian, eight, receiving, adhere, chose, 【제목키워드】 Vaccine, BNT162b2, Strong, heterologous prime-boost immunization,