Background Coronavirus disease 2019 (COVID-19) is suspected to mainly be more deleterious in patients with underlying cardiovascular diseases (CVD). There is a strong association between hypertension and COVID-19 severity. The binding of SARS-CoV-2 to the angiotensin-converting enzyme 2 (ACE2) leads to deregulation of the renin-angiotensin-aldosterone system (RAAS) through down-regulation of ACE2 with subsequent increment of the harmful Ang II serum levels and reduction of the protective Ang-(1–7). Both angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) are commonly used to manage hypertension. Objective Objective was to illustrate the potential link between hypertension and COVID-19 regarding the role of angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) in hypertensive patients with COVID-19. Methods We carried out comprehensive databases search from late December 2019 to early January 2021 by using online engines of Web of Science, Research gate, Scopus, Google Scholar, and PubMed for published and preprinted articles. Results The present study’s findings showed that hypertension is regarded as an independent risk factor for COVID-19 severity. Both ACEIs and ARBs are beneficial in managing hypertensive patients. Conclusion This study concluded that hypertension increases COVID-19 severity due to underlying endothelial dysfunctions and coagulopathy. COVID-19 might augment the hypertensive complications due to down-regulation of ACE2. The use of ACEIs or ARBs might be beneficial in the management of hypertensive patients with COVID-19.
【저자키워드】 SARS-CoV-2, Coronavirus disease 2019, ACE2, hypertension, 【초록키워드】 COVID-19, COVID-19 severity, cardiovascular disease, angiotensin-converting enzyme 2, database, Endothelial dysfunction, Coagulopathy, ARB, management, Patient, Complication, RAAS, Ang II, Protective, binding, association, ACEi, angiotensin receptor blocker, angiotensin-converting enzyme inhibitor, ACEIs, ARBs, Deleterious, Google Scholar, reduction, CVD, Web of Science, Serum level, hypertensive, down-regulation, independent risk factor, deregulation, hypertensive patients, objective, articles, Result, carried, subsequent, increase, hypertensive patient, with COVID-19, 【제목키워드】 COVID-19, management,