In May 2021, the Alpha variant (B.1.1.7) of SARS-CoV-2 was found in 91% of the SARS-CoV-2 cases in Germany. Not much is known about the symptoms, courses of disease, and infectiousness in pediatric patients with the Alpha variant. Objective: The aim of this retrospective analysis was to gain information on the infection with the Alpha variant in children and adolescents. Methods: Between 12 January 2021 and 3 June 2021, all nucleic acid amplification tests (NAATs) of children who received a swab for SARS-CoV-2 were included. Data were collected on standardized questionnaires. The analysis of data was anonymized and retrospective. Results: We investigated 3544 NAATs; 95 children were tested positive (2.7%) for SARS-CoV-2. For the sub-analysis, 65 children were analyzed. In 59 children, the Alpha variant was found (90.8%), and 54.2% ( n = 32/59) were symptomatic. The most common symptoms were fever, cough, and rhinitis. The median Ct value was 24.0 (min 17.0; max 32.7). Conclusions: We can underline early findings that children are still less effected by SARS-CoV-2 infection with the spread of the Alpha variant. We found no evidence that children infected with the Alpha variant showed more severe symptoms or suffered from a more severe clinical course than those infected with the wild type.
【저자키워드】 COVID-19, children, Germany, Alpha, Ct-value, 【초록키워드】 SARS-CoV-2, SARS-COV-2 infection, Infection, Symptom, cough, Symptoms, Spread, nucleic acid, Clinical course, Germany, B.1.1.7, infectiousness, symptomatic, Pediatric patients, Fever, Ct value, Retrospective analysis, Alpha, Swab, Alpha variant, nucleic acid amplification, information, disease, wild type, Evidence, retrospective, Analysis, Questionnaires, Pediatric patient, positive, rhinitis, courses, Course, tested, analyzed, collected, investigated, median, less, suffered, severe symptom, the SARS-CoV-2, 【제목키워드】 SARS-CoV-2, Test, Alpha, experience, acid,