Neurological long-term sequelae are increasingly considered an important challenge in the recent COVID-19 pandemic. However, most evidence for neurological symptoms after SARS-CoV-2 infection and central nervous system invasion of the virus stems from individuals severely affected in the acute phase of the disease. Here, we report long-lasting cognitive impairment along with persistent cerebrospinal fluid anti-SARS-CoV-2 antibodies in a female patient with unremarkable standard examination 6 months after mild COVID-19, supporting the implementation of neuropsychological testing and specific cerebrospinal fluid investigation also in patients with a relatively mild acute disease phase. Supplementary Information The online version contains supplementary material available at 10.1186/s42466-021-00135-y.
【저자키워드】 COVID-19, SARS-CoV-2, Cognitive impairment, Neurologic sequelae, CSF antibodies, 【초록키워드】 SARS-COV-2 infection, COVID-19 pandemic, virus, anti-SARS-CoV-2 antibody, implementation, female, Patient, Mild, Central nervous system, cerebrospinal fluid, disease, Evidence, Invasion, supplementary material, acute phase, individual, Neurological symptom, affected, the disease, long-lasting, increasingly, 【제목키워드】 anti-SARS-CoV-2 antibody, Mild, cerebrospinal fluid, persistent,