During COVID-19, immature granulocyte (IG) concentration is heterogeneous with higher concentrations than those found in bacterial sepsis. We investigated the relationship between IG levels at ICU admission and on days 7 (± 2) and 15 (± 2) and associated pulmonary bacterial infections in intensive care unit (ICU) patients hospitalized for an acute respiratory distress syndrome (ARDS) related to SARS-CoV-2. Patients with associated pulmonary bacterial infection had a peak of IGs. IG thresholds of 18% or 2 G/L allowed discriminating patients with ventilator associated pneumonia with 100% sensitivity and specificity. Our study supports that IGs could help identifying pulmonary bacterial infections in this population. Supplementary Information The online version contains supplementary material available at 10.1186/s40560-021-00575-3.
【저자키워드】 COVID-19, Biomarker, secondary infections, immature granulocytes, Ventilator-associated pneumonia, 【초록키워드】 SARS-CoV-2, ARDS, intensive care, ICU, Sensitivity and specificity, Patient, ICU admission, Bacterial infection, threshold, Bacterial sepsis, acute respiratory distress, Concentration, granulocyte, Support, Ventilator associated pneumonia, supplementary material, syndrome, help, heterogeneous, investigated, immature, patients hospitalized, 【제목키워드】 Severe COVID-19 pneumonia, Diagnosis, Patient, Bacterial infection, granulocyte, help,