Abstract Background The impact of SARS-CoV-2 alongside influenza is a major concern in the northern hemisphere as winter approaches. Methods Test data for influenza and SARS-CoV-2 from national surveillance systems between 20 January 2020 and 25 April 2020 were used to estimate influenza infection on the risk of SARS-CoV-2 infection. A test-negative design was used to assess the odds of SARS-CoV-2 in those who tested positive for influenza compared with those who tested negative. The severity of SARS-CoV-2 was also assessed using univariable and multivariable analyses. Results The risk of testing positive for SARS-CoV-2 was 58% lower among influenza-positive cases and patients with a coinfection had a risk of death of 5.92 (95% confidence interval: 3.21–10.91) times greater than among those with neither influenza nor SARS-CoV-2. The odds of ventilator use or death and intensive care unit admission or death were greatest among coinfected patients. Conclusions Coinfection of these viruses could have a significant impact on morbidity, mortality and health-service demand.
【저자키워드】 SARS-CoV-2, Epidemiology, Influenza, Coinfection, Interaction, 【초록키워드】 Mortality, intensive care, SARS-COV-2 infection, severity, Test, risk, virus, Surveillance, morbidity, Patient, death, Admission, patients, risk of death, ventilator, approaches, influenza infection, National, multivariable analyses, positive, Result, greater, tested, was used, were used, univariable, 【제목키워드】 disease,