Neonatal COVID-19 is rare and mainly results from postnatal transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), however, can infect the placenta and compromise its function. We present two cases of decreased fetal movements and abnormal fetal heart rhythm 5 days after mild maternal COVID-19, requiring emergency caesarean section at 29 + 3 and 32 + 1 weeks of gestation, and leading to brain injury. Placental examination revealed extensive and multifocal chronic intervillositis, with intense cytoplasmic positivity for SARS-CoV-2 spike antibody and SARS-CoV-2 detection by RT-qPCR. Vertical transmission was confirmed in one case, and both neonates developed extensive cystic peri-ventricular leukomalacia.
【저자키워드】 COVID-19, SARS-CoV-2, MRI, Perinatal, placental, brain injury, fetal movements, neurosonography, 【초록키워드】 severe acute respiratory syndrome coronavirus 2, coronavirus, Placenta, antibody, Transmission, severe acute respiratory syndrome Coronavirus, Brain, SARS-CoV-2 detection, RT-qPCR, Neonate, Caesarean section, Mild, fetal movements, vertical transmission, respiratory, SARS-CoV-2 spike, Injury, gestation, acute respiratory syndrome, acute respiratory syndrome coronavirus, leukomalacia, Neonatal COVID-19, infect, cytoplasmic, fetal, 【제목키워드】 SIGN, Decreased,