The SARS-CoV-2 pandemic is one of the most concerning health problems around the globe. We reported the emergence of SARS-CoV-2 variant B.1.1.519 in Mexico City. We reported the effective reproduction number (Rt) of B.1.1.519 and presented evidence of its geographical origin based on phylogenetic analysis. We also studied its evolution via haplotype analysis and identified the most recurrent haplotypes. Finally, we studied the clinical impact of B.1.1.519. The B.1.1.519 variant was predominant between November 2020 and May 2021, reaching 90% of all cases sequenced in February 2021. It is characterized by three amino acid changes in the spike protein: T478K, P681H, and T732A. Its Rt varies between 0.5 and 2.9. Its geographical origin remain to be investigated. Patients infected with variant B.1.1.519 showed a highly significant adjusted odds ratio (aOR) increase of 1.85 over non-B.1.1.519 patients for developing a severe/critical outcome ( p = 0.000296, 1.33–2.6 95% CI) and a 2.35-fold increase for hospitalization ( p = 0.005, 1.32–4.34 95% CI). The continuous monitoring of this and other variants will be required to control the ongoing pandemic as it evolves.
【저자키워드】 SARS-CoV-2, Phylogenetic analysis, B.1.1.519 variant, effective reproduction number, haplotype analysis, clinical impact, significant adjusted odds ratio, COVID-19 hospitalization, COVID-19 critical outcome, 【초록키워드】 Evolution, pandemic, Hospitalization, SARS-CoV-2 pandemic, variant, SARS-CoV-2 variant, haplotypes, outcome, continuous monitoring, Spike protein, Phylogenetic analysis, Health, Patient, Reproduction number, haplotype analysis, clinical impact, P681H, Amino acid, Evidence, evidence of, health problems, Mexico City, T478K, adjusted odds ratio, 95% CI, other variants, problem, effective, amino acid change, sequenced, globe, reported, investigated, required, characterized, predominant, concerning, other variant, 【제목키워드】 clinical, Impact, landscape,