Coinfection rates with other pathogens in coronavirus disease 2019 (COVID-19) varied during the pandemic. We assessed the latest prevalence of coinfection with viruses, bacteria, and fungi in COVID-19 patients for more than one year and its impact on mortality. A total of 436 samples were collected between August 2020 and October 2021. Multiplex real-time PCR, culture, and antimicrobial susceptibility testing were performed to detect pathogens. The coinfection rate of respiratory viruses in COVID-19 patients was 1.4%. Meanwhile, the rates of bacteria and fungi were 52.6% and 10.5% in hospitalized COVID-19 patients, respectively. Respiratory syncytial virus, rhinovirus, Acinetobacter baumannii , Escherichia coli , Pseudomonas aeruginosa , and Candida albicans were the most commonly detected pathogens. Ninety percent of isolated A. baumannii was non-susceptible to carbapenem. Based on a multivariate analysis, coinfection (odds ratio [OR] = 6.095), older age (OR = 1.089), and elevated lactate dehydrogenase (OR = 1.006) were risk factors for mortality as a critical outcome. In particular, coinfection with bacteria (OR = 11.250), resistant pathogens (OR = 11.667), and infection with multiple pathogens (OR = 10.667) were significantly related to death. Screening and monitoring of coinfection in COVID-19 patients, especially for hospitalized patients during the pandemic, are beneficial for better management and survival.
【저자키워드】 COVID-19, SARS-CoV-2, Mortality, Prevalence, Coinfection, resistance, 【초록키워드】 coronavirus disease, viruses, Coronavirus disease 2019, pandemic, Risk factors, susceptibility, Infection, outcome, hospitalized patients, risk factor, virus, lactate dehydrogenase, Screening, respiratory viruses, Coinfection, survival, Culture, pathogen, Real-time PCR, rhinovirus, respiratory virus, respiratory syncytial virus, management, Older age, death, Pathogens, Bacteria, respiratory, fungi, Critical, COVID-19 patients, Multivariate analysis, Lactate, Candida albicans, Analysis, Pseudomonas aeruginosa, Odds ratio, COVID-19 patient, Escherichia coli, antimicrobial susceptibility, carbapenem, hospitalized COVID-19 patients, Acinetobacter, elevated lactate dehydrogenase, performed, detect, collected, significantly, hospitalized patient, Candida albican, 【제목키워드】 clinical, Impact,