Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) descriptions of infection and transmission have been increasing in companion animals in the past year. Although canine susceptibility is generally considered low, their role in the COVID-19 disease cycle remains unknown. In this study, we detected and sequenced a delta variant (AY.3) from a 12-year-old Collie living with owners that previously tested positive for SARS-CoV-2. It is unclear if the dogs’ symptoms were related to SARS-CoV-2 infection or underlying conditions. The whole genome sequence obtained from the dog sample had several unique consensus level changes not previously identified in a SARS-CoV-2 genome that may play a role in the rapid adaptation from humans to dogs. Within the spike coding region, 5/7 of the subconsensus variants identified in the dog sequence were also identified in the closest in-house human reference case. Taken together, the whole genome sequence, and phylogenetic and subconsensus variant analyses indicate the virus infecting the animal originated from a local outbreak cluster. The results of these analyses emphasize the importance of rapid detection and characterization of SARS-CoV-2 variants of concern in companion animals.
【저자키워드】 COVID-19, SARS-CoV-2, delta variant, dog, AY.3, canine, 【초록키워드】 severe acute respiratory syndrome coronavirus 2, coronavirus, SARS-COV-2 infection, susceptibility, Human, variant, SARS-CoV-2 variant, Infection, Local, Transmission, Symptom, severe acute respiratory syndrome Coronavirus, delta variant, virus, COVID-19 disease, SARS-CoV-2 variants, outbreak, SARS-CoV-2 genome, animal, Cluster, respiratory, underlying conditions, change, Phylogenetic, characterization, Consensus, acute respiratory syndrome, acute respiratory syndrome coronavirus, house, sequence, coding region, description, positive, whole genome sequence, infecting, tested, sequenced, unique, analysis, Collie, 【제목키워드】 Delta, USA, Identified,