The deleterious effects of the coronavirus disease 2019 (COVID-19) pandemic urged the development of diagnostic tools to manage the spread of disease. Currently, the “gold standard” involves the use of quantitative real-time polymerase chain reaction (qRT-PCR) for SARS-CoV-2 detection. Even though it is sensitive, specific and applicable for large batches of samples, qRT-PCR is labour-intensive, time-consuming, requires trained personnel and is not available in remote settings. This review summarizes and compares the available strategies for COVID-19: serological testing, Point-of-Care Testing, nanotechnology-based approaches and biosensors. Last but not least, we address the advantages and limitations of these methods as well as perspectives in COVID-19 diagnostics. The effort is constantly focused on understanding the quickly changing landscape of available diagnostic testing of COVID-19 at the clinical levels and introducing reliable and rapid screening point of care testing. The last approach is key to aid the clinical decision-making process for infection control, enhancing an appropriate treatment strategy and prompt isolation of asymptomatic/mild cases. As a viable alternative, Point-of-Care Testing (POCT) is typically low-cost and user-friendly, hence harbouring tremendous potential for rapid COVID-19 diagnosis.
【저자키워드】 detection, point of care testing, Epidemic, SARS-CoV-2 variants, 【초록키워드】 COVID-19, Treatment, coronavirus disease, infection control, pandemic, qRT-PCR, point of care, diagnostic, diagnostics, Spread, SARS-CoV-2 detection, Testing, Serological testing, COVID-19 diagnosis, POCT, Isolation, disease, Quantitative, Perspective, effort, limitation, approach, polymerase chain, time-consuming, deleterious effect, Last, 【제목키워드】 SARS-CoV-2, battle,