Background: We aimed to compare the clinical severity in patients who were coinfected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and rhinovirus or monoinfected with a single one of these viruses. Methods: The study period ranged from 1 March 2020 to 28 February 2021 (one year). SARS-CoV-2 and other respiratory viruses were identified by real-time reverse-transcription-PCR as part of the routine work at Marseille University hospitals. Bacterial and fungal infections were detected by standard methods. Clinical data were retrospectively collected from medical files. This study was approved by the ethical committee of our institute. Results: A total of 6034/15,157 (40%) tested patients were positive for at least one respiratory virus. Ninety-three (4.3%) SARS-CoV-2-infected patients were coinfected with another respiratory virus, with rhinovirus being the most frequent (62/93, 67%). Patients coinfected with SARS-CoV-2 and rhinovirus were significantly more likely to report a cough than those with SARS-CoV-2 monoinfection (62% vs. 31%; p = 0.0008). In addition, they were also significantly more likely to report dyspnea than patients with rhinovirus monoinfection (45% vs. 36%; p = 0.02). They were also more likely to be transferred to an intensive care unit and to die than patients with rhinovirus monoinfection (16% vs. 5% and 7% vs. 2%, respectively) but these differences were not statistically significant. Conclusions: A close surveillance and investigation of the co-incidence and interactions of SARS-CoV-2 and other respiratory viruses is needed. The possible higher risk of increased clinical severity in SARS-CoV-2-positive patients coinfected with rhinovirus warrants further large scale studies.
【저자키워드】 COVID-19, SARS-CoV-2, severity, Coinfection, rhinovirus, 【초록키워드】 viruses, coronavirus, intensive care, intensive care unit, severe acute respiratory syndrome Coronavirus, cough, hospitals, respiratory viruses, Surveillance, rhinovirus, respiratory virus, clinical, Dyspnea, Patient, respiratory, university, Clinical severity, Interaction, Marseille, Other respiratory viruses, Fungal infection, acute respiratory syndrome, higher risk, these viruses, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, Clinical data, study period, SARS-CoV-2-positive patients, bacterial and fungal infections, ethical committee, positive, another respiratory virus, tested, collected, significantly more, addition, approved, statistically significant, other respiratory virus, ranged, SARS-CoV-2-infected patient, SARS-CoV-2-positive patient, transferred, 【제목키워드】 rhinovirus,