Abstract Background Patients with coronavirus disease 2019 (COVID‐19) often suffer sudden deterioration of disease around 1‐2 weeks after onset. Once the disease progressed to severe phase, clinical prognosis of patients will significantly deteriorate. Methods This was a multicenter retrospective study on patients of all adult inpatients (≥18 years old) from Tianyou Hospital (Wuhan, China) and the Fourth Affiliated Hospital, Zhejiang University School of Medicine. All 139 patients had laboratory‐confirmed COVID‐19 in their early stage, which is defined as within 7 days of clinical symptoms. Univariate and multivariate logistic regression models were used to determine the predictive factors in the early detection of patients who may subsequently develop into severe cases. Results Multivariable logistic regression analysis showed that the higher level of hypersensitivity C‐reactive protein (OR = 4.77, 95% CI:1.92‐11.87, P = .001), elevated alanine aminotransferase (OR = 6.87, 95%CI:1.56‐30.21, P = .011), and chronic comorbidities (OR = 11.48, 95% CI:4.44‐29.66, P < .001) are the determining risk factors for the progression into severe pneumonia in COVID‐19 patients. Conclusion Early COVID‐19 patients with chronic comorbidities, elevated hs‐CRP or elevated ALT are significantly more likely to develop severe pneumonia as the disease progresses. These risk factors may facilitate the early diagnosis of critical patients in clinical practice. Early COVID‐19 patients with chronic comorbidities, elevated hs‐CRP or increased ALT are significantly more likely to develop severe pneumonia as disease progresses
【저자키워드】 COVID‐19, Cytokine storm, Risk factors, SARS‐CoV‐2, laboratory parameter, 【초록키워드】 coronavirus disease, Clinical symptoms, Comorbidities, Comorbidity, progression, risk factor, COVID‐19, Medicine, Retrospective study, early diagnosis, Deterioration, Patient, severe cases, School, multicenter, severe pneumonia, university, disease, Critical, early stage, Clinical practice, ALT, hypersensitivity, Predictive, alanine aminotransferase, Inpatient, Clinical prognosis, Factor, Logistic regression analysis, COVID‐19 patients, multivariate logistic regression, C‐reactive protein, Zhejiang, Wuhan, China, Result, defined, develop, significantly more, significantly, the disease, elevated, facilitate, were used, determine, COVID‐19 patient, deteriorate, progressed, 【제목키워드】 retrospective, criteria, Severe case, COVID‐19 patient,