Background Knowledge about COVID-19 infections is expanding, although knowledge about the disease course and antibody formation in patients with an auto-immune disease or immunodeficiency is not fully unraveled yet. It could be hypothesized that immunodeficient patients, due to immunosuppressive drugs or their disease, have a more severe disease course due to their immunocompromised state. However, it could also be hypothesized that some of the immunosuppressive drugs protect against a hyperinflammatory state. Methods We collected data on the incidence of COVID-19, disease course and SARS-CoV-2 antibody formation in COVID-19 positive patients in a cohort of patients (n = 4497) known at the Clinical Immunology outpatient clinic in a tertiary care hospital in the Netherlands. Results In the first six months of the pandemic, 16 patients were identified with COVID-19, 14 by nasal swab PCR, and 2 patients by SARS-CoV-2 antibodies. Eight patients were admitted to the hospital. SARS-CoV-2 antibodies were measured in 8 patients and were detectable in all, including one patient on B-cell ablative therapy and one patient with Common Variable Immunodeficiency Disorder. Conclusion This study indicates that the disease course differs among immunocompromised patients, independently of (dis)continuation of immunosuppressive drugs. Antibody production for SARS-CoV-2 in immunocompromised patients was shown. More research needs to be conducted to confirm these observations and guidelines regarding (dis)continuation of immunosuppressive drugs in COVID-19 positive immunocompromised patients should be developed. Highlights • The disease course of COVID-19 largely differs among immunocompromised individuals. • Antibody production against SARS-CoV-2 is noticed in immunocompromised patients. • Further recommendations on (dis)continuation on immunosuppressive drugs during a COVID-19 infection are needed.
【저자키워드】 COVID-19, antibodies, Immunocompromised, Immunosuppressive agents, Immunologic deficiency syndromes, 【초록키워드】 SARS-CoV-2, pandemic, therapy, knowledge, hospital, immunodeficiency, Immunocompromised patients, Immunocompromised patient, immunosuppressive drugs, SARS-CoV-2 antibodies, PCR, SARS-CoV-2 antibody, COVID-19 infection, clinical, Research, Patient, nasal swab, disease, Care, B-cell, antibody formation, hyperinflammatory state, Netherlands, observation, outpatient clinic, immunocompromised individuals, collected data, disease course, positive, variable, severe disease course, recommendation, immunodeficient patients, auto-immune disease, common, PROTECT, Course, Result, shown, detectable, the disease, conducted, indicate, were measured, cohort of patient, COVID-19 positive patient, immunosuppressive drug, incidence of COVID-19, with COVID-19, 【제목키워드】 immunology, COVID-19 infection, Patient, antibody formation,