Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22–42, aa 79–84, and aa 330–393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species.
【저자키워드】 SARS-CoV-2, ACE2, bioinformatics, Transmission, viral spike receptor-binding domain, 【초록키워드】 COVID-19, pandemic, ACE2 receptor, coronavirus 2, Protein, SARS-CoV-2 transmission, RBD, receptor, respiratory, Amino acid, ACE2 protein, severe coronavirus disease, comprehensive analysis, enzyme, domain, cellular receptor, human cell, bind, carried, reported, 【제목키워드】 Flow,