The inflammatory mediator and oxidant agent storm caused by the SARS-CoV-2 infection has been strongly associated with the failure of vital organs observed in critically ill patients with coronavirus disease 2019 (COVID-19) and the death of thousands of infected people around the world. Acute kidney injury (AKI) is a common renal disorder characterized by a sudden and sustained decrease in renal function with a critical influence on poor prognosis and lethal clinical outcomes of various etiologies, including some viral infection diseases. It is known that oxidative stress and inflammation play key roles in the pathogenesis and development of AKI. Quercetin is a natural substance that has multiple pharmacological properties, such as anti-inflammatory action, and is used as a dietary supplement. There is evidence of the anti-coronavirus activities of this compound, including against the target SARS-CoV-2 3CLpro. The ability to inhibit coronavirus and its inflammatory processes is strongly desired in a new drug for the treatment of COVID-19. Therefore, in this review, the dual effect of quercetin is discussed from a mechanistic perspective in relation to AKI kidney injury and its nephroprotective potential to SARS-CoV-2 patients.
【저자키워드】 coronavirus, SARS-CoV, natural products, flavonoids, medicinal plants, antioxidant, anti-inflammatory activity, Middle East Respiratory Syndrome Virus, nephroprotective activity, renoprotective activity, 【초록키워드】 COVID-19, Treatment, coronavirus disease, SARS-CoV-2, Inflammation, viral infection, Diseases, Infection, dietary supplement, quercetin, 3CLpro, oxidative stress, renal function, Kidney injury, Clinical outcome, AKI, death, Critical, SARS-CoV-2 patients, Evidence, Inflammatory, Critically ill patient, Perspective, poor prognosis, anti-inflammatory action, disorder, renal, organ, pharmacological, anti-coronavirus activity, decrease, inflammatory mediator, etiologies, caused, inhibit, characterized, sustained, pathogenesis and development, the SARS-CoV-2, 【제목키워드】 aspect, Potential,